报告题目：Linkage between Neuroengineering and Neuroscience
报告人：Hsin-Yi Lai (賴欣怡)博士
地点： 电信楼SEIEE 2-314会议室
How do neurons work? Neuroengineering uses engineering techniques to understand, repair, replace, enhance, or otherwise exploit the properties of neural systems. The engineers use the engineering principles to develop quantitative tools and methods for the neuroscience research. Scientists use these neurotechnologies for understanding the complex neural computation and behavior via recording and processing neural activities, as well as improve and repair brain function through stimulating the neurons. My research interests attend to the development of the bio-micro-electro-mechanical systems (BioMEMS) sensor, the neural information processing system, the neural imaging and the neural coding and decoding for understanding and modeling the complex neural systems. To better understand the neuron network in the brain, I have developed a flexible and MR-compatible multichannel neural probe that can be used to both neural recording and stimulation for long-term study. Besides in vivo study, a multifunctional microelectrode array chip was designed to simultaneous monitor the action potential and dopamine for in vitro study. In addition, I developed the automatic spike sorting algorithm and hardware for the online neural signal processing. After the neural signal capture devices and a spike sorting method were produced, I am going to use these tools for investigating the neurovascular responses of deep brain stimulation in the rat’s basal ganglia and for modeling the tactile motion perception in the non-human primate’s somatosensory cortex. In summary, I sought to develop novel neurotechnologies for understanding neural coding and translational research.
Hsin-Yi Lai received her Ph.D. degrees in Electrical Control Engineering from the National Chiao Tung University, Hsinchu, Taiwan, in 2011. In 2012-2013, she was a postdoctoral research fellow of the Department of Neurology, University of North Carolina, Chapel Hill, USA. She used blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) to map brain responses to deep brain stimulation at the subthalamic nucleus and the internal globus pallidus in a rat model. She also fabricated a MR-compatible multichannel electrode for recording and stimulating neurons under MRI. She is currently a Senior Postdoctoral Research fellow at the Somatosensory Laboratory in Chang Gung University and Chang Gung Memorial Hospital, Taoyuan, Taiwan. She has published over 25 SCI journal papers, including Neuroimage, Biosensors and Bioelectronics, Experimental Neurology, Neurobiology of Disease, Nature: Journal of Cerebral Blood Flow & Metabolism, and Journal of Neural Engineering, and 9 journal articles under review. She was selected/nominated for more than 15 international awards since 2008, including 2014 Magna Cum Laude Merit Award from 22th ISMRM; 2013 Summa Cum Laude Merit Award from 21th ISMRM; 2013 Young Investigator Travel Award from 26th Brain ISCBFM et al. Dr. Lai’s research interest involves the BioMEMS sensor, functional MRI, in vivo optical microscopy, neural information processing system and neural coding in the sensory system, and clinically-related electrophysiology studies.