副教授
金卫林
发布时间:2017-03-08 

职称:副研究员
研究方向:转化神经科学,肿瘤分子治疗和免疫治疗基础
办公室
办公电话:021-34206375
电子邮箱:weilinjin@sjtu.edu.cn
个人主页
招生情况

个人介绍


金卫林,男,医学博士,上海交通大学国家转化医学中心、纳米生物医学工程研究所副研究员。1994年,毕业于武汉大学生物化学专业,获学士学位后应招入伍。进入第四军医大学全军神经科学研究所任助教。2004年,师从著名神经生物学家鞠躬院士获医学博士学位。2005年底转业人才引进到上海交通大学,被聘为上海交通大学副研究员。
近五年来主持四项国家自然科学基金委的面上项目和作为学术骨干,参与多项国家“973”重大项目的研究。实验室主要研究方向为转化神经科学。重点开展脑肿瘤分子治疗和免疫治疗方面的基础和转化方面的研究。相关研究成果已经整理论文发表在Cell(2篇)、Cancer Res、Biomaterials、Cell Death and Differention、Nature Communications (2篇)、Oncotarget (2篇)、Cell Death and Disease、Cancer Letter等国际重要专业杂志上。总影响因子超270。研究成果被Nature杂志,Cancer Res杂志重点介绍。实验室研究成果被国际广泛关注和引用(Google Scholar 超过1400次)。ESI高被引论文2篇。
 

学术兼职


现为中国神经科学学会会员;中国抗癌协会纳米肿瘤学专业委员会委员;国家自然科学基金委通讯评审;众多重要国际专业杂志,如Oncotarget, Cancer Letters, Molecular Neurobiology, PloS One,Cancer Science,International Journal of Biological Sciences,Tumor Biology, Mol Cell Neurosci, Chemical Biology & Drug Design, Cellular & Molecular Biology Letters等特约审稿人;同时担任《Stem Cell Epigenetics》,《Precision Medicine》、《转化医学电子杂志》等多种杂志的编委。
 

教育经历


1. 2001/08-2004/06, 第四军医大学,基础医学部,博士,导师:鞠躬
2. 1998/09-2001/06, 第四军医大学,基础医学部,硕士,导师:鞠躬
3.  1990/09-1994/07,武汉大学,生物系生化专业,学士
 

工作经历


2015/01-至今,上海交通大学,电子信息与电气工程学院,副研究员
2005/12-2014/12,上海交通大学,生命科学技术学院,副研究员
2004/07-2005/11,第四军医大学,基础医学部,讲师
1994/07-1998/08, 第四军医大学,基础医学部,助教
 
 

主持的科研项目


1.  国家自然科学基金面上项目,81272801,Nogo-A介导氧化还原成瘾信号在恶性胶质瘤发生发展中的作用机制研究,2013/01-2016/12,70万元,在研,主持
2.  国家自然科学基金面上项目,31171033,精神发育迟滞候选基因MEGAP/srGAP3调控树突发育的双模态机制研究,2012/01—2015/12,65万元,已结题,主持
3.  国家自然科学基金面上项目,30970936,神经元Nogo剪接异构体对突起生长和细胞凋亡的双重调控作用及其机制研究,2010/01-2012/12,30万元,已结题,主持
4.  国家自然科学基金面上项目,30770671,nNos基因作为神经元细胞核Nogo-A蛋白的靶标研究,2008/01-2010/12,26万元,已结题,主持
 

研究方向


研究方向主要集中在:转化神经科学;肿瘤分子治疗和免疫治疗基础
 

代表论文


Representative Publications

  1. Gao J, Ma Y, Fu HL, Luo Q, Wang Z, Xiao YH, Yang H, Cui DX and Jin WL*. Non-catalytic roles for TET1 protein negatively regulating neuronal differentiation through srGAP3 in neuroblastoma cells. Protein Cell. 2016 May; 7(5):351-61.
  2. Mao XY*, Dai JX, Zhou HH, Liu ZQ*, Jin WL*.Brain tumor modeling using the CRISPR/Cas9 system: state of the art and view to the future. Oncotarget. 2016 Mar 14. doi: 10.18632/oncotarget.8075. [Epub ahead of print]
  3. Mao XY*, Tokay T, Zhou HH, Jin WL*. Long-range and short-range tumor-stroma networks synergistically contribute to tumor-associated epilepsy. Oncotarget. 2016 Mar 7. doi: 10.18632/oncotarget.7962. [Epub ahead of print] Review.
  4. Lin XB#, Jiang L#, Ding MH, Chen ZH, Bao Y, Chen Y, Sun W, Zhang CR, Hu HK, Cai Z, Lu CY, Zhou JY, Qian J, Wu XJ, Jin WL*, Hu GH*. Anti-tumor activity of phenoxybenzamine hydrochloride on malignant glioma cells. Tumour Biol. 2016 Mar;37(3):2901-8.
  5. Li L, Deng B, Wang S, Zhong H, Liu Z, Jin W, Jiang T, Xiao Z, Wang Q. synchronous therapy targeting Nogo-A enhances neurobehavioral recovery by reducing neuronal loss and promoting neurite outgrowth after cerebral ischemia in mice. J Drug Target. 2016;24(1):13-23.
  6. Xu CJ*.#, Wang JL#, Jin WL*. The Emerging Therapeutic Role of NGF in Alzheimer's Disease. Neurochem Res. 2016 Jan 22. [Epub ahead of print]
  7. Dai Jinxiang, Bercury Kathryn, Jin Weilin and Macklin Wendy*. Olig1 acetylation and nuclear export mediate oligodendrocyte development. The Journal of Neuroscience, December 2, 2015, 35(48):15875–15893. 
  8. Wang B, Ma A, Zhang L, Jin WL, Qian Y, Xu G, Qiu B, Yang Z, Liu Y, Xia Q, Liu Y. POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation.Nat Commun. 2015 Oct 29;6:8704. doi: 10.1038/ncomms9704.
  9. Li C, Ruan J, Yang M, Pan F, Gao G, Qu S, Shen YL, Dang YJ, Wang K, Jin WL, Cui DX*. Human induced pluripotent stem cells labeled with fluorescent magnetic nanoparticles for targeted imaging and hyperthermia therapy for gastric cancer. Cancer Biol Med. 2015 Sep;12(3):163-74. doi: 10.7497/j.issn.2095-3941.2015.0040.
  10. Mi, Y#.; Gao, X#.; Dai, J.; Ma, Y.; Xu, L*.; Jin, W*. A Novel Function of TET2 in CNS: Sustaining Neuronal Survival. Int. J. Mol. Sci. 2015, 16, 21846-21857.
  11. Ding MH#, Wang Z#, Jiang L#, Fu HL, Gao J, Lin XB, Zhang CL, Liu ZY, Shi YF, Qiu GZ, Ma Y, Cui DX, Hu GH*, Jin WL*. The transducible TAT-RIZ1-PR protein exerts histone methyltransferase activity and tumor-suppressive functions in human malignant meningiomas. Biomaterials 2015 Jul; 56 (3): 165-178. doi: 10.1016/j.biomaterials.2015.03.058
  12. Zhang J, Song Y, Zhang C, Zhi X, Fu H, Ma Y, Chen Y, Pan F, Wang K, Ni J, Jin W, He X*, Su H*, Cui D*. Circulating MiR-16-5p and MiR-19b-3p as Two Novel Potential Biomarkers to Indicate Progression of Gastric Cancer. Theranostics 2015; 5(7):733-745. doi:10.7150/thno.10305.
  13. Xu CJ*, Wang JL, Jin WL*. The Neural Stem Cell Microenvironment: Focusing on Axon Guidance Molecules and Myelin-Associated Factors. J Mol Neurosci. 2015 Mar 11. [Epub ahead of print]
  14. Zhang C, Zhou Z, Zhi X, Ma Y, Wang K, Wang Y, Zhang Y, Fu H, Jin W, Pan F, Cui D. Insights into the Distinguishing Stress-induced Cytotoxicity of Chiral Gold Nanoclusters and the Relationship with GSTP1. Theranostics 2015; 5(2):134-149. doi:10.7150/thno.10363.
  15. Mi, Y. #*, Gao, X#., Ma, Y., Gao, J., Wang, Z., and Jin, W.L.* A novel centrosome and microtubules associated subcellular localization of Nogo-A: implications for neuronal development, International Journal of Biochemistry and Cell Biology. 2014 December, 57:1-6
  16. Xing-Chun Gao#*, Ya-Jing Mi#, Yue Ma, Weilin Jin*. LEF1 regulates glioblastoma cell proliferation, migration, invasion, and cancer stem-like cell self-renewal. Tumour Biol. 2014 Nov. 35:11505–11511.
  17. Xing-Chun Gao, Weilin Jin*. The Emerging Role of Tumor-Suppressive MicroRNA-218 in Targeting Glioblastoma Stemness. Cancer Lett. 2014 Oct 10; 353(1):25-31. doi: 10.1016/j.canlet.2014.07.011. Epub 2014 Jul 17.
  18. Hua-Lin Fu, Yue Ma, Lun-Gen Lu, Peng Hou, Baojie Li, Weilin Jin*, and Da-Xiang Cui*. TET1 Exerts Its Tumor Suppressor Function by Interacting with p53-EZH2 Pathway in Gastric Cancer. J. Biomed. Nanotechnol. 2014. 10, 1217-1230.
  19. Xiang-Hui Zhao#*, Jin-Xiang Dai#, Yue Ma, Ya-Jing Mi, Daxiang Cu, Gong Ju, Wendy B. Macklin, Weilin Jin*. Dynamics of Tet hydroxylase family proteins and 5-hydroxymethylcytosine in oligodendrocyte differentiation. Glia. 2014; 62(6):914-26.
  20. Yun-Kai Dai#, Yue Ma #, Keng Chen #, Ya-Jing Mi, Hua-Lin Fu, Da-Xiang Cui and Weilin Jin*. A link between the nuclear-localized srGAP3 and the SWI/SNF chromatin remodeler Brg1. Mol Cell Neurosci. 2014, 60: 10-25.
  21. He N, Jin WL, Lok K-H, Wang Y, M Yin* and Wang Z-J *. Amyloid-β1-42 oligomer accelerates senescence in adult hippocampal neural stem/progenitor cells via formylpeptide receptor 2. Cell Death & Disease 2013; 4:e924. doi: 10.1038/cddis.2013.437.
  22. Yanyang Tu#, Xingchun Gao#, Gang Li #, Hualin Fu, Daxiang Cui, Hui Liu, Weilin Jin*, Yongsheng Zhang *. MicroRNA-218 Inhibits Glioma Invasion, Migration, Proliferation and Cancer Stem-like Cell Self-renewal by Targeting the Polycomb Group Gene Bmi1. Cancer Res. 2013; 73(19); 6046–6055.
  23. BREAKING ADVANCES: Highlights from Recent Cancer Literature. Cancer Res., Oct 2013; 73: 6097 - 6098.
  24. BREAKING ADVANCES: Highlights from Recent Cancer Literature. Cancer Res.,Sep 2013; 73: 5607 - 5608.
  25. Qi Yang, Kexia Wu, Meiju Ji, Weilin Jin, He N, Shi B, Hou P. Decreased 5-hydroxymethylcytosine (5-hmC) is an independent poor prognostic factor in gastric cancer patients. J Biomed Nanotechnol. 2013; 9(9):1607-1616.
  26. Haixia Lu, Qian Jiao, Yuanyuna Wang, Zhiqiang Yang, Mianjuan Feng, Li Wang, Xinlin Chen, Weilin Jin*, Yong Liu *. The mental retardation associated protein srGAP3 regulates survival, proliferation and differentiation of rat embryonic neural stem/progenitor cells. Stem Cells and Development. 2013, 22(11): 1709-1716.
  27. Fang Guo #, Weilin Jin #, Liya Li, Wenying Song, Huiwen Wang, Xiaochun Gou, Yajing Mi, Qiang Wang, Lize Xiong. M9, A Novel Region of Amino-Nogo-A, Attenuates Cerebral Ischemic Injury by Inhibiting NADPH Oxidase-Derived Superoxide Production in Mice. CNS Neurosci Ther. 2013; 19(5):319-328.
  28. Fang Guo, Huiwen Wang, Liya Li, Heng Zhou, Haidong Wei, Weilin Jin, Qiang Wang, Lize Xiong. A Novel Domain of Amino-Nogo-A Protects HT22 Cells Exposed to Oxygen Glucose Deprivation by Inhibiting NADPH Oxidase Activity. Cell Mol Neurobiol. 2013; 33(3): 443-452
  29. Yue Ma, Ya-Jing Mi, Yun-Kai Dai, Hua-Lin Fu, Daxiang Cui, Jin Weilin*. The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells. Plos One. 2013 Mar 7; e57865.
  30. Ningning Niu, Wanqi Liang, XijiaYang, Weilin Jin, Zoe A Wilson, Jianping Hu, Dabing Zhang. EAT1 promotes tapetal cell death by regulating aspartic proteases during male reproductive development in rice. Nat Commun. 2013 Feb 5;4:1445.
  31. Guo Gao,* Chunlei Zhang, Zhijun Zhou, Xin Zhang, Jiebing Ma, Chao Li, Weilin Jin*, Daxiang Cui*. One-pot hydrothermal synthesis of lanthanide ions doped one-dimensional upconversion submicrocrystals and their potential application in vivo CT imaging. Nanoscale. 2013; 5(1):351-62.
  32. Jun Chen, Wei Wang, Tao Zhang, Jia Ji, Qirong Qian, Lungeng Lu, Hualin Fu, Weilin Jin, Daxiang Cui. Differential expression of phospholipase C epsilon 1 is associated with chronic atrophic gastritis and gastric cancer. PLoS One. 2012; 7(10):e47563.
  33. Charrier C,Joshi K,Coutinho-Budd J , Kim J, Lambert N, Jacqueline de Marchena, Weilin Jin, Vanderhaeghen P, Ghosh A, Sassa K and Franck Polleux. Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny of spine maturation. Cell; 2012; 149(4) :923-935.
  34. News&Views in Nature by Geschwind and Konopka. Highlights in Nature by Ewen Callaway. Discover Magazine by Ed Yong. New Scientist by Sara Reardon.
  35. Ya-Jing MI, Bing Hou, Qiu-Ming Liao , Yue Ma, Qian Luo,Yun-Kai Dai , Gong Ju Weilin Jin*. Amino-Nogo-A antagonizes reactive oxygen species generation and protects immature primary cortical neurons from oxidative toxicity. Cell Death & Differentiation. 2012 Jul; 19 (7):1175-86.
  36. Keng Chen, Yajing Mi, Yue Ma, Hualin Fu, Weilin Jin*. The mental retardation associated protein, srGAP3 negatively regulates VPA-induced neuronal differentiation of Neuro2A cells. Cell Mol Neurobiol. 2011; 31(5):675-686.
  37. Sabrice Guerrier, Jaeda Coutinho-Budd, Takayuki Sassa, Aurélie Gresset, Nicole Vincent Jordan, Keng Chen, Wei-Lin Jin, Adam Frost, Franck Polleux. The F-BAR Domain of srGAP2 Induces Membrane Protrusions Required for Neuronal Migration and Morphogenesis. Cell, Volume 138, Issue 5, 990-1004, 4 September 2009.
  38. News&Views in Nature by Geschwind and Konopka. Highlights in Nature by Ewen Callaway. Discover Magazine by Ed Yong. New Scientist by Sara Reardon.
 
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